HATU CAS 148893-10-1 Peptide Coupling Reagent Purity >99.5% (HPLC) Factory

Short Description:

Chemical Name: HATU

CAS: 148893-10-1

Purity: >99.5% (HPLC)

Appearance: White Crystalline Powder

Peptide Coupling Reagent, High Quality

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of HATU (CAS: 148893-10-1) with high quality. Ruifu Chemical supplys a series of protecting reagents and coupling reagents. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase HATU (CAS: 148893-10-1), Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	HATU
Synonyms	1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-Oxide Hexafluorophosphate; N,N,N',N'-Tetramethyl-O-(7-Azabenzotriazol-1-yl)uronium Hexafluorophosphate; O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-Tetramethyluronium Hexafluorophosphate
Stock Status	In Stock, Mass Production, Adequate Stock
CAS Number	148893-10-1
Molecular Formula	C10H15N6O·PF6
Molecular Weight	380.23 g/mol
Melting Point	183.0~188.0℃
Sensitive	Moisture Sensitive, Heat Sensitive
Solubility	Soluble in Acetonitrile. Insoluble in Water
Storage Temp.	Cool & Dry Place (≤4℃, Away from Light)
COA & MSDS	Available
Category	Coupling Reagents
Brand	Ruifu Chemical

Specifications:

Items	Inspection Standards	Results
Appearance	White Crystalline Powder	Complies
Melting Point	183.0~188.0℃	184.1~185.8℃
Loss on Drying	<0.50%	0.10%
Heavy Metals (Pb)	≤20ppm	<20ppm
Purity / Analysis Method	>99.5% (HPLC) (on Dry Basis)	99.9%
Infrared Spectrum	Conforms to Structure	Complies
NMR Spectrum	Conforms to Structure	Complies
Solution Test (in ACN)	Clear and Transparent	Complies
Conclusion	The product has been tested & complies with the given specifications

Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Moisture sensitive. Store in sealed containers at cool and dry (≤4℃) warehouse away from incompatible substances. Protect from light, heat and moisture.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

148893-10-1 - Risk and Safety:

Risk Codes
R36/37/38 - Irritating to eyes, respiratory system and skin.
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R2 - Risk of explosion by shock, friction, fire or other sources of ignition
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection
S36/37 - Wear suitable protective clothing and gloves.
S36 - Wear suitable protective clothing.
S35 - This material and its container must be disposed of in a safe way.
UN IDs 1325
WGK Germany 3
RTECS XZ5633000
FLUKA BRAND F CODES 10-21
HS Code 2933990099
Hazard Class 4.1
Packing Group Ⅱ

Application:

HATU (CAS: 148893-10-1) is a peptide coupling reagent and used in peptide synthesis. HATU is used in the reaction of carboxyl group and amino group to synthesize peptide bond. HATU is also involved efficiently to speed up the coupling process and reduces the loss of chiral integrity.
Peptide coupling reagent; use solid-phase synthesis method to prepare N-arylsulfonamide-linked peptides; the latest research shows that the crystal and solution structure of the coupling agent is guanidine salt N-oxide, not urea cationic compound; effective coupling agent in solid-phase peptide synthesis.
HATU belongs to the guanidinium group of coupling reagents ( HBTU, TBTU, HCTU, TCTU). Most efficient coupling reagent, showing less epimerization during coupling in SPPS/Fmoc protocols. A “golden standard” in SPPS peptide chemistry, difficult couplings, and fragment condensation.
HATU is a highly active coupling reagent that often produces superior results in difficult couplings compared to HBTU. Coupling reactions utilizing HATU generally are faster, produce higher yields and less racemization.
Reagent for: Synthesis of Aurora A kinase inhibitors; Amide bond formation reactions. Catalyst for: Selective acylation; Selecocyclization-oxidation deselenation sequence; Preparation of N-arylsulfonamide-linked peptides by solid-phase synthesis.